Dorsomorphin
Product Sizes
5 mg
£118.00
KS-300-5MG
About this Product
- SKU:
- KS-300
- Additional Names:
- Compound C, BML 275|KS-300, KS300, KS 300, Dorsomorphin, 866405-64-3, Compound C, BML 275, BML275
- CAS Number:
- 866405-64-3
- Extra Details:
- Dorsomorphin is an ATP competitive inhibitor of AMP-activated protein kinase (AMPK) with a Ki of 109 nM and no significant activity on several structurally related kinases including ZAPK, SYK, PKCI, PKA and JAK3. Dorsomorphin inhibits the bone morphogenetic protein (BMP) type I receptors ALK2, ALK3 and ALK6, and promotes cardiomyogenesis in mouse embryonic stem cells (ESCs) in vitro as well as promoting neural differentiation of human pluripotent stem cells as part of a chemical cocktail. Dorsomorphin can be used in a protocol to generate brain organoids from human induced pluripotent stem cells. In vivo, dorsomorphin can inhibit formalin-induced inflammatory nociception in mice.
- Immunogen:
- Kinases,Receptor serine/threonine kinase receptors
- Molecular Weight:
- 399.49
- Physical State:
- Solid
- Purity:
- 98% by TLC, NMR conforms
- Sequence:
- 6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine
- Shipping Conditions:
- Blue Ice
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
