A 769662
Product Sizes
5 mg
£130.00
KS-290-5MG
About this Product
- SKU:
- KS-290
- Additional Names:
- KS-290, KS290, KS 290, A-769662, A769662, A 769662
- CAS Number:
- 844499-71-4
- Extra Details:
- A 769662 is a potent and reversible AMP-activated protein kinase (AMPK) allosteric activator with an EC50 of 0.8 uM, that displays selectivity towards B Beta1 subunit-containing heterotrimers, activating AMPK by binding to the B Beta and I³ subunits and not the AMP binding site. AMPK is a key cellular energy sensor and regulator of metabolic homeostasis and activation of AMPK provides beneficial outcomes in fighting against metabolic disorders such as insulin resistance and type 2 diabetes. In vivo, A 769662 inhibits fatty acid biosynthesis in rat hepatocytes and decreases plasma glucose and triglyceride levels. In ob/ob mice, A-769662 inhibits the rate of whole-body fatty acid oxidation, decreases body weight gain, reduces triglycerides and lowers glucose levels. A 769662 also inhibits proliferation of mesenchymal stem cells and impedes reprogramming of mouse embryonic fibroblasts to induced pluripotent stem cells (iPSCs).
- Immunogen:
- Kinases
- Molecular Weight:
- 360.39
- Physical State:
- Solid
- Purity:
- 98% by HPLC, NMR conforms
- Sequence:
- 4-Hydroxy-3-(2²-hydroxy-[1,1²-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile
- Shipping Conditions:
- Blue Ice
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
