Torin 1
Product Sizes
5 mg
£130.00
KS-270-5MG
About this Product
- SKU:
- KS-270
- Additional Names:
- mTOR Inhibitor XI|Torin 1, Torin-1, Torin1, KS-270, KS270, KS 270, 1222998-36-8, mTOR Inhibitor XI
- CAS Number:
- 1222998-36-8
- Extra Details:
- Torin 1 is a potent and selective ATP-competitive mammalian target of rapamycin (mTOR) inhibitor, with IC50 values of 2 and 10 nM for mTORC1 and mTORC2 respectively and 200-fold selectivity over ATM, DNA-PK, and hVps34: additionally it does not significantly inhibit a panel of 353 serine/threonine, tyrosine, and lipid kinases at 10 uM. Torin 1 impairs cell growth and proliferation by suppression of the rapamycin-resistant functions of mTORC1 and has also been shown to cause cell cycle arrest via a rapamycin-resistant mechanism independent of mTORC2. Torin 1 induces autophagy, and in animal models, also has anti-inflammatory, anti-cancer, and anti-aging properties and shows activity against neuropathic pain.
- Immunogen:
- Kinases
- Molecular Weight:
- 607.62
- Physical State:
- Solid
- Purity:
- 98% by HPLC. NMR conforms
- Sequence:
- 1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one
- Shipping Conditions:
- Blue Ice
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
