CHIR 99021
Product Sizes
5 mg
£118.00
KS-260-5MG
About this Product
- SKU:
- KS-260
- Additional Names:
- CHIR-99021, CHIR 99021, CHIR99021, KS260. KS-260, KS 260, 252917-06-9, CT99021, CT-99021, Laduviglusib|CT99021, Laduviglusib
- CAS Number:
- 252917-06-9
- Extra Details:
- CHIR 99021 is a potent and highly selective inhibitor of glycogen synthase kinase 3 (GSK-3), with IC50 values of 6.7 and 10 nM for GSK-3B Beta and GSK-3A Alpha respectively, and greater than >500-fold selectivity for GSK-3 over closely related kinases. CHIR 99021 in combination with other agents can be used to reprogram mouse embryonic fibroblasts into induced pluripotent stem cells (iPSCs) and can also enhance mouse and human embryonic stem cell (ESC) self-renewal and promote differentiation of human pluripotent stem cells (hPSCs) in cardiomyocytes. CHIR 99021 is used in a protocol to generate brain organoids from human iPSCs.
- Immunogen:
- Kinases
- Molecular Weight:
- 465.35
- Physical State:
- Solid
- Purity:
- 99% by TLC, NMR conforms
- Sequence:
- 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
