Y 27632 dihydrochloride
Product Sizes
5 mg
£118.00
KS-250-5MG
About this Product
- SKU:
- KS-250
- Additional Names:
- KS250, KS-250, KS 250, 129830-38-2, Y-27632 dihydrochloride, Y27632 dihydrochloride, Y 27632 dihydrochloride, ROCK inhibitor, ROCK1 inhibitor|ROCK inhibitor, ROCK1 inhibitor
- CAS Number:
- 129830-38-2
- Extra Details:
- Y 27632 is a selective inhibitor of the Rho-associated coiled-coil forming protein serine/threonine kinase (ROCK) family of protein kinases, with Ki's of 140 nM and 300nM against ROCK1 and ROCK2 respectively, and greater than 200-fold selectivity over other kinases. Y 27632 is cell-permeable, orally bioavailable and active in vivo, and can enhance stem cell survival and proliferation in culture. In combination with other agents, Y 27632 can be used to reprogram fibroblasts to mature neurons and can optimise naive human pluripotent stem cell (iSPC) growth and viability. Y 27632 has been used used to generate brain organoids from iPSCs.
- Immunogen:
- Kinases
- Molecular Weight:
- 320.26
- Physical State:
- Solid
- Purity:
- 99% by HPLC, NMR conforms
- Sequence:
- (R)-(+)-trans-4-(1-Aminoethyl)-N-(-4-pyridyl)cyclohexanecarboxamide dihydrochloride
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
