Octpep-1
Product Sizes
1 mg
£130.00
KS-240-1MG
About this Product
- SKU:
- KS-240
- Additional Names:
- KS-240. KS240, DPPSDDEFVSLM, Octpep-1
- Extra Details:
- Octpep-1 is a peptide derived from the octopus kaurna, or the southern sand octopus, a species native to the seas around the Great Australian Bight and Tasmania. Octpep-1 disrupts PI3K/AKT/mTOR pathway signalling and selectively reduces the proliferative capacity of human melanoma BRAFV600E mutated cells, with minimal effects on fibroblasts. Octpep-1 has weak agonist activity at tachykinin NK1 receptors but its antiproliferative activity is independent of NK1R expression. Octpep-1 acts synergistically in combination with the mTORC1 inhibitor rapamycin or the ERK1/2 inhibitor LY3214996 to enhance its antiproliferative effects and augment cytotoxicity. Octpep-1 reduces the progression of tumours in vivo, being effective in xenograft mouse melanoma and zebrafish models.
- Immunogen:
- Kinases,Tachykinin receptors
- Molecular Weight:
- 1350.56
- Physical State:
- Freeze dried solid
- Purity:
- >98%
- Sequence:
- H-Asp-Pro-Pro-Ser-Asp-Asp-Glu-Phe-Val-Ser-Leu-Met-OH
- Shipping Conditions:
- Blue Ice
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
