MLCK inhibitor peptide 18
About this Product
- SKU:
- KS-180
- Additional Names:
- MLCK inhibitor peptide 18, 224579-74-2|Myosin Light Chain Kinase Inhibitor Peptide 18, Peptide 18
- CAS Number:
- 224579-74-2
- Extra Details:
- MLCK inhibitor peptide 18 is a selective cell permeable inhibitor of myosin light chain kinase with an IC50 of 50 nM. MLCK inhibitor peptide 18 displays 4000-fold selectivity over CaM kinase II and does not inhibit PKA. In vitro and in vivo treatment with the MLCK inhibitor peptide 18 attenuates the increased epithelial monolayer permeability and occludin endocytosis caused by intestinal anoxia/reoxygenation (A/R) injury.
- Immunogen:
- Kinases
- Molecular Weight:
- 1324.64
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Lukas et al (1999) Identification of novel classes of protein kinase inhibitors using combinatorial peptide chemistry based on functional genomics knowledge. J.Med.Chem. <strong>42</strong> 910 <a href="https://pubmed.ncbi.nlm.nih.gov/10072688/" target="_blank" rel="nofollow">PMID: 10072688</a></p><p>Jin and Blikslager (2016) Myosin light chain kinase mediates intestinal barrier dysfunction via occludin endocytosis during anoxia/reoxygenation injury. American J. Physiology-Cell Physiology <strong>311(</strong>6) C996 <a href="https://pubmed.ncbi.nlm.nih.gov/27760753/" target="_blank" rel="nofollow">PMID: 27760753</a></p><p>Huang et al (2020) Wogonoside alleviates colitis by improving intestinal epithelial barrier function via the MLCK/pMLC2 pathway. Phytomedicine <strong>68</strong> 153179 <a href="https://pubmed.ncbi.nlm.nih.gov/32062328/" target="_blank" rel="nofollow">PMID: 32062328</a></p><p>Guide to Pharmacology:<a href="https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=9351" target="_blank" rel="nofollow"> MLCK inhibitor peptide 18</a></p>
- Sequence:
- H-Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-Arg-Lys-NH2
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble to 1 mg/ml in water
- Formula:
- C60H105N23O11
