ZIP
About this Product
- SKU:
- KS-170
- Additional Names:
- z-Pseudosubstrate inhibitory peptide, Zeta inhibitory peptide, PKCI (113-125), myristoylated|ZIP, 863987-12-6, Myr-SIYRRGARRWRKL, z-Pseudosubstrate inhibitory peptide, PKCI (113-125), myristoylated, KS-170, KS170
- CAS Number:
- 863987-12-6
- Extra Details:
- ZIP, or Zeta inhibitory peptide, is a cell permeable pseudo-substrate inhibitor of protein kinase MI (PKMI ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. ZIP selectively blocks PKMI induced synaptic potentiation in hippocampal slices in vitro and is widely used to investigate memory in a variety of learning tasks, including spatial sensitization, pain sensitization, fear-associated memories, conditioned taste aversion and development of locomotor sensitization in rodents. However, LTP and LTM are unaffected in both constitutive and conditional PKMI knock-out mice, yet both are still impaired by ZIP application, suggesting another mechanism of action which may involve ionotropic glutamate AMPA receptors (AMPARs).
- Immunogen:
- Kinases
- Molecular Weight:
- 1928.4
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Serrano et al (2005) Persistent phosphorylation by protein kinase Mz maintains late-phase long-term potentiation. J.Neurosci. <strong>25</strong> 1979 <a href="https://pubmed.ncbi.nlm.nih.gov/15728837/" target="_blank" rel="nofollow">PMID: 15728837</a></p><p>LeBlancq et al (2016) ZIP It: Neural Silencing Is an Additional Effect of the PKM-Zeta Inhibitor Zeta-Inhibitory Peptide. J. Neuroscience <strong>36</strong> (23) 6193<a href="https://pubmed.ncbi.nlm.nih.gov/27277798/" target="_blank" rel="nofollow"> DOI: 10.1523/JNEUROSCI.4563-14.2016</a></p><p>Bingor et al (2020) Zeta Inhibitory Peptide attenuates learning and memory by inducing NO-mediated downregulation of AMPA receptors. Nat Commun <strong>11</strong> 3688 <a href="https://pubmed.ncbi.nlm.nih.gov/32703948/" target="_blank" rel="nofollow">https://doi.org/10.1038/s41467-020-17484-y</a></p>
- Sequence:
- Myr-Ser-Ile-Tyr-Arg-Arg-Gly-Ala-Arg-Arg-Trp-Arg-Lys-Leu-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble to 1 mg/ml in water
- Formula:
- C90H154N30O17
