R18
About this Product
- SKU:
- KS-120
- Additional Names:
- 211364-78-2, H-PHCVPRDLSWLDLEANMCLP-OH, PHCVPRDLSWLDLEANMCLP, R18, R18 peptide, 14.3.3 proteins, KS-120, KS120|R18 peptide
- CAS Number:
- 211364-78-2
- Extra Details:
- R18, also known as R18 peptide is an antagonist of 14.3.3 proteins, a family of conserved regulatory molecules that have the ability to bind a multitude of functionally diverse signaling proteins, with a KD of approximately 80 nM. R18 competitively inhibits 14.3.3 ligand interactions without requiring phosphorylation and can block the ability of 14.3.3 to bind to target proteins such as Raf-1, Bad, ASK1 and exoenzyme S.
- Immunogen:
- Protein-protein interactions,Kinases
- Molecular Weight:
- 2309.6
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Wang et al (1999) Isolation of high-affinity peptide antagonists of 14.3.3 proteins by phage display. Biochemistry <strong>38</strong> 12499 PMID: 10493820 </p><p>Masters et al (2002) Survival-promoting functions of 14.3.3 proteins. Biochem.Soc.Transactions <strong>30</strong> 360 </p><p>De Vries-van Leeuwen et al (2013) ERα activation is controlled by 14-3-3 proteins. Proc. Nat. Acad. Sci. <strong>110</strong>(22) 8894 DOI: 10.1073/pnas.1220809110</p>
- Sequence:
- H-Pro-His-Cys-Val-Pro-Arg-Asp-Leu-Ser-Trp-Leu-Asp-Leu-Glu-Ala-Asn-Met-Cys-Leu-Pro-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store frozen and desiccated in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in dilute acid
- Formula:
- C101H157N27O29S3
