PKI (14-22) amide, myristoylated
About this Product
- SKU:
- KS-110
- Additional Names:
- 201422-03-9, Myr-GRTGRRNAI-NH2, GRTGRRNAI, PKI (14 - 22) amide, myristoylated, cell-permeable, protein kinase inhibitor, PKI, PKI (14-22) amide, protein kinase A, KS-110, KS110
- CAS Number:
- 201422-03-9
- Extra Details:
- PKI (14 - 22) amide, myristoylated, is a cell-permeable version of the protein kinase inhibitor (PKI) PKI (14-22) amide. When non-myristoylated, PKI (14-22) amide inhibits protein kinase A with a Ki of 36 nM and also inhibits cell growth and induces apoptosis in human pancreatic cancer cells (PANC-1). Myristoylated peptides as a class may exhibit off-target activation of the funny current If in sinoatrial myocytes.
- Immunogen:
- Kinases
- Molecular Weight:
- 1209.5
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Glass et al (1989) Primary structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitory protein. J.Biol.Chem. <strong>264</strong> 8802 PMID: 2722799 </p><p>Farrow et al (2003) Inhibition of pancreatic cancer cell growth and induction of apoptosis with novel therapies directed against protein kinase A. Surgery <strong>134</strong> 197 PMID: 12947318 </p><p>Liao et al (2011) Myristoylated peptides potentiate the funny current I(f) in sinoatrial myocytes. Channels <strong>5</strong>(2) 115 doi:10.4161/chan.5.2.14195</p>
- Sequence:
- Myr-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store desiccated, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in dilute acid and DMSO as a stock solution.
- Formula:
- C53H100N20O12
