PKA inhibitor (6-22) amide
About this Product
- SKU:
- KS-060
- Additional Names:
- PKI(6-22) amide|TYADFIASGRTGRRNAI-NH2, TYADFIASGRTGRRNAI, 121932-06-7, PKA inhibitor (6-22) amide, PKI(6-22) amide, cAMP-dependent protein kinase , PKA, KS-060, KS060
- CAS Number:
- 121932-06-7
- Extra Details:
- PKA inhibitor (6-22) amide, also known as PKI(6-22) amide, is an inhibitor of cAMP-dependent protein kinase (PKA). PKA Inhibitor (6-22) amide is derived from the active section of the heat-stable PKA inhibitor PKI, the endogenous PKA inhibitor protein, and is the shortest synthetic PKI peptide with high potency for PKA inhibition. PKA inhibitor (6-22) amide inhibition of PKA can decrease long-term potentiation (LTP) at hippocampal synapses and reverse morphine tolerance.
- Immunogen:
- Kinases
- Molecular Weight:
- 1868.1
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Glass et al (1989) Primary structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitor protein. J.Biol.Chem. <strong>264</strong> 8802 PMID: 2722799 </p><p>Glass et al (1989) Protein kinase inhibitor-(6-22)-amide peptide analogs with standard and nonstandard amino acid substitutions for phenylalanine <strong>10</strong>. J.Biol.Chem. 264 14579 PMID: 2760075 </p><p>Otmakhova et al (2000) Inhibition of the cAMP pathway decreases early long-term potentiation at CA1 hippocampal synapses. J.Neurosci. <strong>20</strong> 4446 PMID: 10844013</p>
- Sequence:
- H-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store desiccated, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in dilute acid
- Formula:
- C80H130N28O24
