PKI (5-24)
About this Product
- SKU:
- KS-050
- Additional Names:
- PKA inhibitor (5-24)|TTYADFIASGRTGRRNAIHD, 99534-03-9, PKI (5-24), PKA inhibitor (5-24), cAMP-dependent protein kinase A, PKA, KS-050 KS050
- CAS Number:
- 99534-03-9
- Extra Details:
- PKI (5-24), also known as PKA inhibitor (5-24), is a potent (Ki 2.3nM) competitive synthetic peptide inhibitor of cAMP-dependent protein kinase A (PKA) derived from the active domain of the naturally-occurring heat-stable inhibitor protein PKI. PKI (5-24) is only a very weak inhibitor of cGMP-dependent protein kinase (PKG).
- Immunogen:
- Kinases
- Molecular Weight:
- 2222.7
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Cheng et al (1986) A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase. J.Biol.Chem. <strong>261</strong> 989 PMID: 3511044</p><p> Narayana et al (1997) Crystal structure of a polyhistidine-tagged recombinant catalytic subunit of cAMP-dependent protein kinase complexed with the peptide inhibitor PKI(5-24) and adenosine. Biochemistry <strong>36</strong> 4438 PMID: 9109651</p>
- Sequence:
- H-Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dark, frozen and desiccated
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in dilute acid
- Formula:
- C94H148N32O31
