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Proteins and Peptides

LRRKtide

Product Sizes
1 mg
£83.00
KS-010-1MG
Academic Pricing
Please contact us for academic pricing.
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About this Product
SKU:
KS-010
Additional Names:
LRRKtide, peptide substrate, leucine-rich repeat kinase 2, LRRK2), ERM protein, ezrin, radixin, moesin (amino acids 539-553), Parkinson's disease, RLGRDKYKTLRQIRQ, KS-010, KS010
Extra Details:
LRRKtide is a peptide substrate for leucine-rich repeat kinase 2 (LRRK2). The sequence of LRRKtide has been derived from the ERM protein family members ezrin (amino acids 561-573), radixin (amino acids 558-570) and moesin (amino acids 539-553), proteins which influence cytoskeletal dynamics by anchoring the cytoskeleton to the plasma membrane. LRRK2 phosphorylates LRRKtide at its Thr558 site. LRRK2 is found in most organs and is involved in several cellular pathways. The LRRK2 gene and A Alpha-synuclein gene (SNCA) are the key influencing factors of Parkinson's disease (PD), with dysfunction of LRRK2 influencing the accumulation of A Alpha-synuclein.
Immunogen:
Kinases
Molecular Weight:
1931.28
Physical State:
Freeze dried solid
Purity:
>95%
References:
<p>Jaleel et al (2007) LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity. Biochem. J. <strong>405</strong> (2) 307<a href="https://pubmed.ncbi.nlm.nih.gov/17447891/" target="_blank" rel="nofollow"> PMID: 17447891</a></p><p>Anand and Braithwaite (2009) LRRK2 in Parkinson's disease: biochemical functions. FEBS J. <strong>276</strong> 6428 <a href="https://pubmed.ncbi.nlm.nih.gov/19804416/" target="_blank" rel="nofollow">doi:10.1111/j.1742-4658.2009.07341.x</a></p><p>Esteves et al (2014) LRRK2, a puzzling protein: Insights into Parkinson's disease pathogenesis. Exp. Neurol. <strong>261</strong> 206 <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194231/" target="_blank">PMID: 24907399</a></p>
Sequence:
H-Arg-Leu-Gly-Arg-Asp-Lys-Tyr-Lys-Thr-Leu-Arg-Gln-Ile-Arg-Gln-OH
Shipping Conditions:
Blue Ice
Storage Conditions:
Store dark, frozen and desiccated
Size:
1 mg
Supplier:
Isca Biochemicals
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
Solubility:
Soluble in dilute acid
Formula:
C83H147N31O22