Kisspeptin 234
Product Sizes
Kisspeptin 234
£129.00
KR-010
About this Product
- SKU:
- KR-010
- Additional Names:
- Peptide 234, p234
- CAS Number:
- 1145998-81-7
- Extra Details:
- Kisspeptin 234 is an analogue of kisspeptin 10 which acts as a kisspeptin receptor antagonist. Of a series, kisspeptin 234 most potently inhibited kisspeptin 10 stimulation of inositol phosphate release in Chinese hamster ovarian cells stably expressing the human GPR54 with an IC50 of 7 nM. Intracerebroventricular administration of kisspeptin 234 causes delayed vaginal opening in rats (an indicator of puberty) and prevents an increase in circulating luteinising hormone concentration when co-administrated with kisspeptin 10.
- Molecular Weight:
- 1295.42
- Purity:
- >95% by hplc
- References:
- <p>Roseweir et al (2009) Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadototrophin regulation. J.Neurosci. <strong>29</strong> 3920 <a href="https://pubmed.ncbi.nlm.nih.gov/19321788/" target="_blank" rel="nofollow">PMID: 19321788</a></p><p>Millar et al (2010) Kisspeptin antagonists: unraveling the role of kisspeptin in reproductive physiology. Brain Res. <strong>1364</strong> 81 <a href="https://pubmed.ncbi.nlm.nih.gov/20858467/" target="_blank" rel="nofollow">PMID: 20858467</a><br></p><p>lbers-Wolthers et al (2017) In vitro and in vivo effects of kisspeptin antagonists p234, p271, p354, and p356 on GPR54 activation. PLoS One <strong>2</strong>(6) e0179156 <a href="https://pubmed.ncbi.nlm.nih.gov/28650956/" target="_blank">PMID: 28650956</a></p>
- Sequence:
- Ac-D-Ala-Asn-Trp-Asn-Gly-Phe-Gly-D-Trp-Arg-Phe-NH2
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Solubility:
- Soluble to 1 mg/ml in water
- Formula:
- C63H78N18O13