Spadin
About this Product
- SKU:
- KC-040
- Additional Names:
- Spadin, 1270083-24-3, YAPLPRWSGPIGVSWGLR
- CAS Number:
- 1270083-24-3
- Extra Details:
- Spadin is a natural peptide released from the maturation of neurotensin receptor 3 (also known as sortilin) which acts as a TREK-1 (TWIK-related K+ channel-1) channel blocker with an IC50 of 71 nM. In electrophysiological studies, spadin blocks the TREK-1 activity in COS-7 cells, in cultured hippocampal pyramidal neurons and CA3 hippocampal neurons in brain slices and in vivo induces an increase of the 5-HT neuron firing rate in the dorsal raphe nucleus. Spadin is brain penetrant, and exhibits antidepressant effects in mouse models of depression with a rapid onset of action and an absence of adverse effects. The antidepressant properties are associated with increased neurogenesis and synaptogenesis in the brain.
- Immunogen:
- Potassium channels
- Molecular Weight:
- 2012.34
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Mazella et al (2010) Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design. PLoS Biol. <strong>8</strong> e1000355 <a href="https://pubmed.ncbi.nlm.nih.gov/20405001/" target="_blank" rel="nofollow">PMID: 20405001</a></p><p>Borsotto et al (2015) Targeting two-pore domain K(+) channels TREK-1 and TASK-3 for the treatment of depression: a new therapeutic concept. Br.J.Pharmacol. <strong>172</strong> 771 <a href="https://pubmed.ncbi.nlm.nih.gov/25263033/" target="_blank">PMID: 25263033</a></p><p>Djillani A, Pietri M, Mazella J, Heurteaux C, Borsotto M. Fighting against depression with TREK-1 blockers: Past and future. A focus on spadin. Pharmacol Ther. <strong>194</strong> 185 <a href="https://pubmed.ncbi.nlm.nih.gov/30291907/" target="_blank" rel="nofollow">PMID: 30291907</a><br></p>
- Sequence:
- H-Tyr-Ala-Pro-Leu-Pro-Arg-Trp-Ser-Gly-Pro-Ile-Gly-Val-Ser-Trp-Gly-Leu-Arg-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble to 2 mg/ml in water
- Formula:
- C96H142N26O22
