Tertiapin LQ
About this Product
- SKU:
- KC-030
- Additional Names:
- Tertiapin LQ, TPNLQ|TPNLQ, TLQ
- Extra Details:
- Tertiapin LQ is a selective blocker of Kir1.1 channels, obtained by modifying tertiapin, the toxin from the honey bee venom. Tertiapin LQ blocks Kir1 with high affinity (1.1 nM) and high selectivity (>250-fold) over many commonly studied Kir subtypes. Application of tertiapin LQ locally in the superficial layers of the cerebellar cortex in decerebrate ferrets suppresses normal performance of Purkinje cell pause responses to the conditional stimulus with no detectable effect on spontaneous firing.
- Immunogen:
- Potassium channels
- Molecular Weight:
- 2428.03
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Ramu et al (2008) Engineered specific and high-affinity inhibitor for a subtype of inward-rectifier K+ channels. Proc.Natl.Acad.Sci.USA <strong>105</strong> 10774 <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2504780/" target="_blank" rel="nofollow">PMID: 18669667</a></p><p>Estrada and Kaufman (2018) µ-Opioid receptors inhibit the exercise pressor reflex by closing N-type calcium channels but not by opening GIRK channels in rats. Am J Physiol Regul Integr Comp Physiol. <strong>314</strong>(5) R693 <a href="https://pubmed.ncbi.nlm.nih.gov/29341826/" target="_blank" rel="nofollow">PMID: 29341826</a></p><p>Johansson and Hesslow (2020) Kir3 channel blockade in the cerebellar cortex suppresses performance of classically conditioned Purkinje cell responses. Sci Rep <strong>10 </strong>15654<a href="https://www.nature.com/articles/s41598-020-72581-8" target="_blank" rel="nofollow"> https://doi.org/10.1038/s41598-020-72581-8</a></p><p><a href="https://pubchem.ncbi.nlm.nih.gov/compound/90488935" target="_blank" rel="nofollow">Pubchem entry for tertiapin LQ</a></p>
- Sequence:
- H-Ala-Leu-Cys*-Asn-Cys*-Asn-Arg-Ile-Ile-Ile-Pro-Leu-Gln-Cys*-Trp-Lys-Lys-Cys*-Gly-Lys-Lys-NH2; disulfide bridges between cysteines 3 - 14 and 5 - 18
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble to 2 mg/ml in 20% acetonitrile / water
- Formula:
- C106H179N33O24S4
