Tertiapin
About this Product
- SKU:
- KC-020
- Additional Names:
- Tertiapin, 403843-29-8, ALCNCNRIIIPHMCWKKCGKK-NH2, ALCNCNRIIIPHMCWKKCGKK|TPN
- CAS Number:
- 403843-29-8
- Extra Details:
- Tertiapin is a peptide found in the venom of the European honey bee (Apis mellifera). Tertiapin is a selective inhibitor of the G-protein-gated atrial K+ channel IKACh that can prolong atrial effective refractory period and terminate atrial fibrillation. Tertiapin is also a selective and potent inhibitor of muscarinic K+ channels in rabbit cardiac myocytes. The methionine residue at position 13 of tertiapin is sensitive to oxidation, reducing ability to block ion channels, so the methionine may be be substituted by glutamine in order to prevent oxidation, resulting in tertiapin-Q, which shows no functional change and is a more suitable research tool for some applications.
- Immunogen:
- Potassium channels
- Molecular Weight:
- 2455.07
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Gauldie et al (1976) The peptide components of bee venom. Eur J Biochem. <strong>61</strong>(2):369 doi: 10.1111/j.1432-1033.1976.tb10030.x</p><p>Hashimoto et al (2006) Tertiapin, a selective IKACh blocker, terminates atrial fibrillation with selective atrial effective refractory period prolongation. Pharmacol Res. <strong>54</strong>(2) 136 doi: 10.1016/j.phrs.2006.03.021</p><p>Patel et al (2020) Structural Determinants Mediating Tertiapin Block of Neuronal Kir3.2 Channels. Biochemistry <strong>59</strong>(7) 836 https://doi.org/10.1021/acs.biochem.9b01098<br></p>
- Sequence:
- H-Ala-Leu-Cys-Asn-Cys-Asn-Arg-Ile-Ile-Ile-Pro-His-Met-Cys-Trp-Lys-Lys-Cys-Gly-Lys-Lys-NH2; disulphide bridges between Cys-3 and Cys-14 and Cys-5 and Cys-18
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark. Protect from air.
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in water to 1 mg/m
- Formula:
- C106H176N34O23S5
