Tertiapin Q
About this Product
- SKU:
- KC-010
- Additional Names:
- ALCNCNRIIIPHQCWKKCGKK-NH2, ALCNCNRIIIPHQCWKKCGKK, 910044-56-3, TPNQ, KC010, KC-010|TPNQ, TPN(Q)
- CAS Number:
- 910044-56-3
- Extra Details:
- Tertiapin-Q is a high affinity blocker of inward-rectifier K+ channels. Tertiapin-Q is a stable derivative of the bee venom toxin tertiapin where the methionine residue at position 13 has been replaced with glutamine, which is far less susceptible to oxidation by air. Tertiapin-Q and native tertiapin have very similar pharmacologucal properties. Tertiapin-Q also binds to ROMK1 (Kir1.1) and GIRK1/4 (Kir3.1/3.4) channels with high affinity (Ki values are 1.3 and 13.3 nM respectively) and shows selectivity over Kir2.1 channels.
- Immunogen:
- Potassium channels
- Molecular Weight:
- 2452
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Jin and Lu (1999) Synthesis of a stable form of tertiapin: a high-affinity inhibitor for inward-rectifier K+ channels. Biochemistry 38 14286 PMID: 10572003</p><p>Jin et al (1999) Mechanisms of inward-rectifier K+ channel inhibition by tertiapin-Q. Biochemistry <strong>38</strong> 14294 PMID: 10572004</p><p>Kanjhan et al (2005) Tertiapin-Q blocks recombinant and native large conductance K+ channels in a use-dependent manner. J Pharmacol Exp Ther. 314(3):1353 doi: 10.1124/jpet.105.085928. Epub 2005 Jun 9. PMID: 15947038<br></p><p><br></p>
- Sequence:
- H-Ala-Leu-Cys-Asn-Cys-Asn-Arg-Ile-Ile-Ile-Pro-His-Gln-Cys-Trp-Lys-Lys-Cys-Gly-Lys-Lys-NH2: disulphide bridges between Cys-3 and Cys-14 and Cys-5 and Cys-18
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble to 2 mg/ml in water
- Formula:
- C106H175N35O24S4
