Dynorphin A
Product Sizes
Dynorphin A
£176.00
KA-010
About this Product
- SKU:
- KA-010
- Additional Names:
- Dyn A 1-17, Dynorphin A (1-17), Dynorphin 17
- CAS Number:
- 80448-90-4
- Extra Details:
- Dynorphins are a class of opioid peptides that arise from the precursor protein prodynorphin, which when cleaved by proprotein convertase 2, releases multiple active peptides including dynorphin A, dynorphin B, and α/β-neo-endorphin. Dynorphin A is an endogenous kappa receptor agonist and has different physiological actions depending upon its site of production. Dynorphin A is a modulator of pain responses and also has roles in weight control, regulating body temperature, and influencing drug seeking behaviour
- Molecular Weight:
- 2147.51
- Purity:
- >95% by hplc
- References:
- <p>Day et al (1998) Prodynorphin processing by proprotein convertase 2. Cleavage at single basic residues and enhanced processing in the presence of carboxypeptidase activity. J Biol Chem.<strong> 273</strong>(2) 829 <a href="https://pubmed.ncbi.nlm.nih.gov/9422738/" target="_blank" rel="nofollow">PMID: 9422738</a></p><p>Lai et al (2006) Dynorphin A activates bradykinin receptors to maintain neuropathic pain. Nat Neurosci. <strong>9</strong>(12) 1534 <a href="https://pubmed.ncbi.nlm.nih.gov/17115041/" target="_blank" rel="nofollow">PMID: 17115041</a></p><p>Redila and Chavkin (2008) Stress-induced reinstatement of cocaine seeking is mediated by the kappa opioid system. Psychopharmacology <strong>200</strong>(1) 59 <a href="https://pubmed.ncbi.nlm.nih.gov/18575850/" target="_blank">PMID: 18575850</a><br></p>
- Sequence:
- H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln-OH
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Solubility:
- Soluble to 0.80 mg/ml in water
- Formula:
- C99H155N31O23