IRBP (651-670) (human)
Product Sizes
IRBP (651-670) (human)
£235.00
IM-050
About this Product
- SKU:
- IM-050
- Additional Names:
- hIRBP651-670, human IRBP651-670
- Extra Details:
- IRBP (651-670) (human), sometimes referred to as hIRBP651-670 or human IRBP651-670, is amino acid residues 651 to 670 of human interphotoreceptor retinoid binding protein (IRBP), which has been identified as a new uveitogenic epitope. IRBP (651-670) (human) is uveitogenic for mice of the H-2b haplotype and elicits experimental autoimmune uveitis (EAU) with a higher severity and incidence in C57BL/6 mice than the previously characterized IRBP (1-20) (human) epitope. Co-immunization with IRBP (1-20) (human) and IRBP (651-670) human is additive but not synergistic. IRBP (651-670) (human) appears to be an epitope naturally processed from a conserved region of native IRBP.
- Molecular Weight:
- 2107.35
- Purity:
- >95% by HPLC
- References:
- <p>Mattapallil et al (2015) Characterization of a New Epitope of IRBP That Induces Moderate to Severe Uveoretinitis in Mice With H-2b Haplotype. Invest. Ophthalmol. Vis. Sci. <strong>56</strong>(9) 5439-49 doi: 10.1167/iovs.15-17280. PMID: 26284549</p><p>Zhang et al (2017) Complement Component C4 Regulates the Development of Experimental Autoimmune Uveitis through a T Cell-Intrinsic Mechanism. Front. Immunol.<strong> 8</strong> 1116 https://www.frontiersin.org/article/10.3389/fimmu.2017.01116</p><p>Tan et al (2020) Small molecules targeting RORγt inhibit autoimmune disease by suppressing Th17 cell differentiation. Cell Death Dis. <strong>11</strong> 697 https://doi.org/10.1038/s41419-020-02891-2 </p>
- Sequence:
- H-Leu-Ala-Gln-Gly-Ala-Tyr-Arg-Thr-Ala-Val-Asp-Leu-Glu-Ser-Leu-Ala-Ser-Gln-Leu-Thr-OH
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Store desiccated, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Solubility:
- Soluble in water
- Formula:
- C91H151N25O32