IRBP (1-20) (human)
Product Sizes
IRBP (1-20) (human)
£118.00
IM-040
About this Product
- SKU:
- IM-040
- CAS Number:
- 298202-25-2
- Extra Details:
- IRBP (1-20) (human) is the 1 to 20 amino acid N-terminal fragment of the interphotoreceptor retinoid binding protein (IRBP). IRBP, also known as retinol binding protein-3 (RBP-3), is a 1264 amino acid residue glycolipoprotein residing in the interphotoreceptor matrix where it is the major extracellular retinoid-binding protein. IRBP is often the target of autoimmune attack and this is one of the leading causes of uveitis. IRBP peptide (1-20) (human) contains a major epitope for the H-2b haplotype and immunization with IRBP (1-20) (human) induces T-cell-mediated experimental autoimmune uveoretinitis (EAU), a widely used rodent model of human disease.
- Molecular Weight:
- 2194.62
- Purity:
- >95% by HPLC
- References:
- <p>Avichezer et al (2000) Identification of a New Epitope of Human IRBP that Induces Autoimmune Uveoretinitis in Mice of the H-2b Haplotype. Invest. Ophthalmol. Vis. Sci. <strong>41</strong>(1) 127 </p><p>Fengqi et al (2009) Role of DAF in Protecting against T-Cell Autoreactivity that Leads to Experimental Autoimmune Uveitis. Invest. Ophthalmol. Vis. Sci. <strong>50</strong>(8) 3778 doi: https://doi.org/10.1167/iovs.08-3264 </p><p>Meng et al (2017) Preventive effect of chrysin on experimental autoimmune uveitis triggered by injection of human IRBP peptide 1-20 in mice. Cell Mol. Immunol. <strong>14</strong> 702 https://doi.org/10.1038/cmi.2015.107</p>
- Sequence:
- H-Gly-Pro-Thr-His-Leu-Phe-Gln-Pro-Ser-Leu- Val- Leu-Asp-Met-Ala-Lys-Val-Leu-Leu-Asp-OH
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Store desiccated, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Solubility:
- Soluble in water
- Formula:
- C101H164N24O28S