E70K
About this Product
- SKU:
- IM-015
- Additional Names:
- Peptide 2
- Extra Details:
- E70K, also known as peptide 2, is the C-terminal CXCL8 peptide fragment CXCL8 (54-72), with a glutamic acid (E) substituted at position 70 with lysine (K) to increase positive charge. Similarly to CXCL8 (54-72), E70K inhibits CXCL8-induced neutrophil transendothelial migration and provides a lead for further development of therapeutic inhibitors of neutrophil-mediated inflammation based on modulation of chemokine-GAG binding.
- Molecular Weight:
- 2400.81
- Purity:
- >95% by HPLC
- References:
- Martínez-Burgo et al (2019), A C-terminal CXCL 8 peptide based on chemokine-glycosaminoglycan interactions reduces neutrophil adhesion and migration during inflammation. Immunol. <strong>157</strong> 173 doi:10.1111/imm.13063
- Sequence:
- Ac-Lys-Glu-Asn-Trp-Val-Gln-Arg-Val-Val-Glu-Lys-Phe-Leu-Lys-Arg-Ala-Lys-Asn-Ser-NH2
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Solubility:
- Soluble in physiological buffers including PBS (>1mg./mL). Soluble in DMSO as a stock solution.
- Formula:
- C108H178N34O28