VnP-16
Product Sizes
1 mg
£165.00
IG-060-1MG
About this Product
- SKU:
- IG-060
- Additional Names:
- Vitronectin derived bioactive peptide|VnP-16, IG-060, IG060, IG 060, VnP16, VnP 16, RVYFFKGKQYWE-NH2, Vitronectin derived bioactive peptide
- Extra Details:
- VnP-16 is a peptide corresponding to residues 270-281 of human vitronectin, which exerts an anti-osteoporotic effect via B Beta1 and A AlphavB Beta3 integrin signaling. VnP-16 promotes bone formation by accelerating osteoblast differentiation through direct interaction with B Beta1 integrin followed by FAK activation, while inhibiting bone resorption through restraint of JNK-c-Fos-NFATc1 induced osteoclast differentiation and A AlphavB Beta3 integrin-c-Src-PYK2 mediated resorption. In a mouse model of estrogen deficiency induced osteoporosis, VnP-16 reverses ovariectomy induced bone loss by increasing osteoblast differentiation and promoting bone formation, while decreasing osteoclastogenesis and inhibiting bone resorption.
- Immunogen:
- Integrin receptors
- Molecular Weight:
- 1648.85
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- Sequence:
- H-Arg-Val-Tyr-Phe-Phe-Lys-Gly-Lys-Gln-Tyr-Trp-Glu-NH2
- Shipping Conditions:
- Blue Ice
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
