Synstatin
About this Product
- SKU:
- IG-050
- Additional Names:
- SSTN, SSTN92-119|Synstatin, IG-050, LPAGEKPEEGEPVLHVEAEPGFTARDKE, SSTN, SSTN92-119, IG050
- Extra Details:
- Synstatin is a peptide derived from amino acids 92-119 of the mouse syndecan sequence and is the active site for the A AlphavB Beta3 and A AlphavB Beta5 integrin activation mechanism. Syndecan is a critical regulator of these two integrins during angiogenesis and tumourigenesis, and this activation process can be blocked by the synstatin peptide. Synstatin displays an IC50 of 100-300 nM when used in vitro to inhibit A AlphavB Beta3 dependent adhesion and cell migration on vitronectin or in aortic ring angiogenesis assays. Synstatin is a potent inhibitor of angiogenesis in vivo and blocks A AlphavB Beta3 mediated tumour cell adhesion and migration and tumour formation in mouse models.
- Immunogen:
- Protein-protein interactions,Integrin receptors
- Molecular Weight:
- 3032.31
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Beauvais et al (2009) Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor. J Exp Med. <strong>206</strong>(3) 691 <a href="https://pubmed.ncbi.nlm.nih.gov/19255147/" target="_blank" rel="nofollow">PMID: 19255147</a><br></p><p>Rapraeger (2013) Synstatin: a selective inhibitor of the syndecan-1-coupled IGF1R-αvβ3 integrin complex in tumorigenesis and angiogenesis. FEBS J. <strong>280</strong>(10) 2207 <a href="https://pubmed.ncbi.nlm.nih.gov/23375101/" target="_blank" rel="nofollow">PMID: 23375101</a></p>
- Sequence:
- H-Leu-Pro-Ala-Gly-Glu-Lys-Pro-Glu-Glu-Gly-Glu-Pro-Val-Leu-His-Val-Glu-Ala-Glu-Pro-Gly-Phe-Thr-Ala-Arg-Asp-Lys-Glu-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in water
- Formula:
- C133H207N35O46
