RGDS peptide
About this Product
- SKU:
- IG-030
- Additional Names:
- RGDS peptide, 91037-65-9, RGDS
- CAS Number:
- 91037-65-9
- Extra Details:
- RGDS peptide is a tetrapeptide found on fibronectin, fibrinogen A Alpha, and von Willebrand factor, but not vitronectin or collagen. RGDS interacts with A Alpha5B Beta1 and A AlphaVB Beta3 integrins and interferes with the attachment of cells to fibronectin coated surfaces and also blocks the attachment of pathogens to cells. The interaction of RGDS peptide with cell surface integrins alters intracellular signaling in a cell and stimulus specific manner.
- Immunogen:
- Integrin receptors
- Molecular Weight:
- 433.42
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Haverstick et al (1985) Inhibition of platelet adhesion to fibronectin, fibrinogen, and von Willebrand factor substrates by a synthetic tetrapeptide derived from the cell-binding domain of fibronectin. Blood. <strong>66</strong>(4) 946 <a href="https://pubmed.ncbi.nlm.nih.gov/3876125/" target="_blank" rel="nofollow">PMID: 3876125</a></p><p>Grigoriou et al (2005) Apoptosis and survival of osteoblast-like cells are regulated by surface attachment. J.Biol.Chem. <strong>280</strong> 1733 <a href="https://pubmed.ncbi.nlm.nih.gov/15522882/" target="_blank" rel="nofollow">PMID: 15522882</a></p><p>Dekkers et al (2010) The integrin-blocking peptide RGDS inhibits airway smooth muscle remodeling in a guinea pig model of allergic asthma. Am J Respir Crit Care Med. <strong>181</strong>(6) 556 <a href="https://pubmed.ncbi.nlm.nih.gov/20019343/" target="_blank">PMID: 20019343</a><br></p>
- Sequence:
- H-Arg-Gly-Asp-Ser-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 5 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble to 1 mg/ml in water
- Formula:
- C15H27N7O8
