PTD2
Product Sizes
1 mg
£106.00
HM-010-1MG
About this Product
- SKU:
- HM-010
- Additional Names:
- PTD2, HM-010, Ac-Gly-Val-Nle-Arg-Ile-NH2, Ac-GVXRI-NH2, HM010, HM 010
- Extra Details:
- PTD2 is a peptide derived from the histone H4 sequence surrounding residue K44 (H4K44) that acts as an inhibitor of Wolf-Hirschhorn syndrome candidate 1 (WHSC1). WHSC1 (also known as NSD2 or MMSET) is a histone 3 lysine 36 (H3K36) specific methyltransferase that is responsible for mono- and dimethylation of lysine 36 on histone H3, and is frequently deleted in the genetic disorder Wolf-Hirschhorn syndrome, and has also been implicated as a driver in a variety of haematological and solid tumours. PTD2 inhibits WHSC1 in biochemical and biophysical assays with similar micromolar potencies, but demonstrates no enzymatic inhibition against a panel of other histone methyltransferases. PTD2 is a valuable tool for in vitro assay development and validation.
- Immunogen:
- Histone methyltransferases
- Molecular Weight:
- 597.76
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- Sequence:
- Ac-Gly-Val-Nle-Arg-Ile-NH2
- Shipping Conditions:
- Blue Ice
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
