SAP15
About this Product
- SKU:
- HD-010
- Additional Names:
- Peptide 3|SAP15, HD-010, HD010, GKCSTRGRKCCRRKK
- Extra Details:
- SAP15 is a cell penetrating peptide corresponding to the last 15 amino acids of the host defense peptide human B Beta-defensin 3, which is involved in adaptive immunity and pro- and anti-inflammatory responses. SAP15 is a histone deacetylase 5 (HDAC5) inhibitor with a dissociation constant of 86 nM in an SPR assay and inhibits lipopolysaccharide (LPS) induced phosphorylation of intracellular HDAC5 and NF- K Kappa B p65 in murine macrophages. In vivo, subcutaneous injection of SAP15-loaded sodium hyaluronic acid solution significantly decreases hind paw swelling, joint inflammation, and serum cytokine levels in a collagen induced arthritis (CIA) rat model.
- Immunogen:
- Histone deacetylases
- Molecular Weight:
- 1767.18
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- Lee et al (2021) Engineered synthetic cell penetrating peptide with intracellular anti-inflammatory bioactivity: An in vitro and in vivo study. J Biomed Mater Res A. <strong>109</strong>(10) 2001 <a href="https://pubmed.ncbi.nlm.nih.gov/33818867/" target="_blank" rel="nofollow">PMID: 33818867</a>
- Sequence:
- H-Gly-Lys-Cys-Ser-Thr-Arg-Gly-Arg-Lys-Cys-Cys-Arg-Arg-Lys-Lys-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in water
- Formula:
- C68 H131N31O18S3
