KRpep-2d
Product Sizes
1 mg
£130.00
GT-010-1MG
About this Product
- SKU:
- GT-010
- Additional Names:
- K-Ras(G12D)-targeting peptide|KRpep-2d, GT-010, GT010, Ac-RRRRC*PLYISYDPVC*RRRR-NH2, 2098181-84-9, K-Ras(G12D)-targeting peptide
- CAS Number:
- 2098181-84-9
- Extra Details:
- KRpep-2d is a potent K-Ras inhibitor, discovered after optimization of an initial hit obtained by phage display technology. KRpep-2d inhibits the enzyme activity of K-Ras(G12D) with an IC50 of 1.6 nM, and with selectivity against wild-type (WT) K-Ras and the K-Ras(G12C) mutant in both cell-free enzyme and cell based assays. Mutated Ras proteins play important roles in cell differentiation, proliferation, and survival of various cancers, and K-Ras(G12D) is considered a very important target as K-Ras mutations underlie 86% of Ras-linked cancers, with 83% of K-Ras mutations being at the G12 residue. KRpep-2d can suppress ERK phosphorylation downstream of K-Ras(G12D) and reduce proliferation in A427 cancer cells.
- Immunogen:
- GTPases
- Molecular Weight:
- 2560.02
- Purity:
- >95%
- Sequence:
- Ac-Arg-Arg-Arg-Arg-Cys*-Pro-Leu-Tyr-Ile-Ser-Tyr-Asp-Pro-Val-Cys*-Arg-Arg-Arg-Arg-NH2; disulfide bridge between cysteines 5 and 15
- Shipping Conditions:
- Blue Ice
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
