[Des-octanoyl]-Ghrelin (human)
About this Product
- SKU:
- GR-010
- Additional Names:
- [Des-octanoyl]-Ghrelin (human), 313951-59-6, GSSFLSPEHQRVQQRKESKKPPAKLQPR, des-acyl ghrelin|Des-acyl ghrelin, Unacylated ghrelin, UAG
- CAS Number:
- 313951-59-6
- Extra Details:
- [Des-octanoyl]-Ghrelin (human) is the more stable, non-acylated and major circulating isoform of ghrelin (human), with a a half-life of 35 min in plasma compared with 10 minutes for acylated ghrelin. Unlike ghrelin, [des-octanoyl]-ghrelin (human) does not bind to the ghrelin receptor (GHS-R1a), or induce growth hormone release. [Des-octanoyl]-ghrelin (human) exerts negative inotropic effects in papillary muscle and displays cardioprotective activity, inhibits cell proliferation in breast and prostate cancer cell lines and promotes adipogenesis in vivo.
- Immunogen:
- Ghrelin receptors
- Molecular Weight:
- 3244.51
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Baldanzi et al (2002) Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT. J.Cell Biol. 159 1029 <a href="https://pubmed.ncbi.nlm.nih.gov/12486113/" target="_blank" rel="nofollow">PMID: 12486113</a></p><p>Gauna et al (2005) Ghrelin stimulates, whereas des-octanoyl ghrelin inhibits, glucose output by primary hepatocytes. J Clin Endocrinol Metab. <strong>90</strong>(2) 1055 <a href="https://pubmed.ncbi.nlm.nih.gov/15536157/" target="_blank" rel="nofollow">PMID: 15536157</a></p><p>Petrescu et al (2020) Ghrelin reverses ductular reaction and hepatic fibrosis in a rodent model of cholestasis. Sci Rep <strong>10</strong> 16024 <a href="https://www.nature.com/articles/s41598-020-72681-5" target="_blank" rel="nofollow">https://doi.org/10.1038/s41598-020-72681-5</a><br></p>
- Sequence:
- H-Gly-Ser-Ser-Phe-Leu-Ser-Pro-Glu-His-Gln-Arg-Val-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble to 1 mg/ml in water
- Formula:
- C141H235N47O41
