TAT-GluR6-9c
Product Sizes
1 mg
£165.00
GL-170-1MG
About this Product
- SKU:
- GL-170
- Additional Names:
- Tat-GluR6-9c|YGRKKRRQRRRRLPGKETMA, GL-170, GL170, TAT-GluR6-9c
- Extra Details:
- TAT-GluR6-9c is a peptide derived from the nine C terminal residues of the kainate receptor subunit GluR6, linked to the cell penetrating sequence TAT. TAT-GluR6-9c is able to perturb the interaction of GluR6 with postsynaptic density protein 95 (PSD-95) and suppress the assembly of the GluR6-PSD-95-mixed lineage protein kinase 3 (MLK3) signalling module, causing inhibition of c-Jun N-terminal kinase (JNK) activation. JNK has an important role during global and focal cerebral ischemia/reperfusion and consistent with JNK inhibition, TAT-GluR6-9c pretreatment decreases neuronal death induced by kainate in vitro. In vivo, TAT-GluR6-9c protects against kainate-induced epileptic seizure and has a neuroprotective effect against ischaemic brain damage, significantly decreasing neuronal degeneration.
- Immunogen:
- Protein-protein interactions,Glutamate (ionotropic) receptors
- Molecular Weight:
- 2542.47
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- Sequence:
- H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Arg-Leu-Pro-Gly-Lys-Glu-Thr-Met-Ala-OH
- Shipping Conditions:
- Blue Ice
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
