TAT-Gap19
About this Product
- SKU:
- GJ-040
- Additional Names:
- TAT-Gap19, TAT Gap19, 1507930-54-2, YGRKKRRQRRRKQIEIKKFK
- CAS Number:
- 1507930-54-2
- Extra Details:
- TAT-Gap19 is a connexin43 (Cx43) hemichannel blocker, with an IC50 of 7 uM and no significant affinity for gap junctions or Panx1 channels. TAT-Gap19 is derived from Gap19, a sequence present on the intracellular cytoplasmic loop domain of Cx43, linked to the HIV-derived TAT internalization sequence to promote membrane permeability, which also allows brain penetration. In mouse models of liver damage, TAT-Gap19 can protect against liver fibrosis accompanied by superoxide dismutase overactivation and reduces production of inflammatory proteins.
- Immunogen:
- Gap junction channels
- Molecular Weight:
- 2703.28
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Abudara et al (2014) The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes. Front.Cell.Neurosci. <strong>8</strong> 1 <a href="https://pubmed.ncbi.nlm.nih.gov/25374505/" target="_blank" rel="nofollow">PMID: 25374505</a></p><p>Crespo et al (2018) TAT-Gap19 and Carbenoxolone Alleviate Liver Fibrosis in Mice. Int J Mol Sci.<strong> 9</strong>(3) 817 <a href="https://pubmed.ncbi.nlm.nih.gov/29534516/" target="_blank" rel="nofollow">PMID: 29534516</a><br></p><p>Ramadan (2020) Connexin43 Hemichannel Targeting With TAT-Gap19 Alleviates Radiation-Induced Endothelial Cell Damage. Front Pharmacol. <strong>11</strong> 212 <a href="https://pubmed.ncbi.nlm.nih.gov/32210810/" target="_blank" rel="nofollow">PMID: 32210810</a></p>
- Sequence:
- H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Lys-Gln-Ile-Glu-Ile-Lys-Lys-Phe-Lys-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble to 1 mg/ml in water
- Formula:
- C119H212N46O26
