Gap 26
About this Product
- SKU:
- GJ-020
- CAS Number:
- 197250-15-0
- Extra Details:
- Gap 26 is a connexin mimetic peptide corresponding to residues 63 - 75 of in the first extracellular loop of connexin 43, which inhibits currents carried by connexin43 hemichannels and gap junction channels. Gap 26 can accelerate wound healing and may have potential in the early treatment of spinal cord injury.
- Molecular Weight:
- 1550.79
- Purity:
- >95% by hplc
- References:
- <p>Braet et al (2003) Photoliberating inositol-1,4,5-trisphosphate triggers ATP release that is blocked by the connexin mimetic peptide gap 26. Cell Calcium<strong> 33</strong> 37 <a href="https://pubmed.ncbi.nlm.nih.gov/12526886/" target="_blank" rel="nofollow">PMID: 12526886</a></p><p>Evans and Leybaert (2007) Mimetic peptides as blockers of connexin channel-facilitated intercellular communication. Cell Commun Adhes. <strong>14</strong>(6) 265 <a href="https://pubmed.ncbi.nlm.nih.gov/18392994/" target="_blank" rel="nofollow">PMID: 18392994</a><br></p><p>Desplantez et al (2012) Gap26, a connexin mimetic peptide, inhibits currents carried by connexin43 hemichannels and gap junction channels. Pharmacol Res. <strong>65</strong>(5) 546 <a href="https://pubmed.ncbi.nlm.nih.gov/22406236/" target="_blank">PMID: 22406236</a></p>
- Sequence:
- H-Val-Cys-Tyr-Asp-Lys-Ser-Phe-Pro-Ile-Ser-His-Val-Arg-OH
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Solubility:
- Soluble to 2 mg/ml in water
- Formula:
- C70H107N19O19S