Gap 27
About this Product
- SKU:
- GJ-010
- Additional Names:
- Connexin43 mimetic peptide, GAP 27, Connexin mimetic peptide, CMP|Gap 27, 198284-64-9, SRPTEKTIFII
- CAS Number:
- 198284-64-9
- Extra Details:
- Gap 27 is a connexin mimetic peptide corresponding to the SRPTEKTIFFI sequence (amino acids 204-214) on the second extracellular loop of connexin43 (Cx43) which is a selective and reversible inhibitor of Cx43 mediated cell-cell communication, which does not influence Cx43 expression levels. Gap27 effectively inhibits gap junction coupling at concentrations of 50 uM in keratinocytes and HeLa43 cells and is a versatile inhibitor of connexin mediated communication in tissue networks, having been used to identify the role of connexins in cardiomyocyte activities and in pathological processes such as epilepsy.
- Immunogen:
- Gap junction channels
- Molecular Weight:
- 1304.55
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Ko et al (2000) Biochemical and functional characterization of intercellular adhesion and gap junctions in fibroblasts. Am.J.Physiol.Cell Physiol.<strong> 279</strong> C147 PMID: 10898726</p><p>Pollok et al (2011), Connexin 43 mimetic peptide Gap27 reveals potential differences in the role of Cx43 in wound repair between diabetic and non-diabetic cells. J. Cellular Molecular Medicine <strong>15</strong> 861 https://doi.org/10.1111/j.1582-4934.2010.01057.x<br></p><p>Faniku et al (2018) The Connexin Mimetic Peptide Gap27 and Cx43-Knockdown Reveal Differential Roles for Connexin43 in Wound Closure Events in Skin Model Systems. International J. Molecular Sciences <strong>19</strong>(2) 604 https://doi.org/10.3390/ijms19020604</p>
- Sequence:
- H-Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble to 1 mg/ml in water
- Formula:
- C60H101N15O17
