[D-Lys3]-GHRP-6
About this Product
- SKU:
- GH-200
- Additional Names:
- [D-Lys3]-GHRP-6, 136054-22-3, HWKWFK, GH-200, GH200|DLys, [D-Lys3]-Growth Hormone Releasing Peptide 6, [His1, D-Lys3, Lys6]-GHRP
- CAS Number:
- 136054-22-3
- Extra Details:
- [D-Lys3]-GHRP-6 is a ghrelin receptor (GHS-R1a) antagonist which also binds weakly to melanocortin receptors. [D-Lys3]-GHRP-6 can decrease energy intake in lean mice, mice with diet induced obesity, and in ob/ob obese mice, and reduces the rate of gastric emptying. [D-Lys3]-GHRP-6 also blocks or reduces ethanol intake and reward seeking in animal models.
- Immunogen:
- Ghrelin receptors
- Molecular Weight:
- 930.12
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Schioth et al (1997) Characterization of the binding of MSH-B, HP-228, GHRP-6 and 153N-6 to the human melanocortin receptor subtypes. Neuropeptides <strong>31</strong> 565 <a href="https://pubmed.ncbi.nlm.nih.gov/9574823/" target="_blank" rel="nofollow">PMID: 9574823</a></p><p>Gomez and Ryabinin (2014) The effects of ghrelin antagonists [D-Lys(3) ]-GHRP-6 or JMV2959 on ethanol, water, and food intake in C57BL/6J mice. Alcohol Clin Exp Res. <strong>38</strong>(9) 2436<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179906/" target="_blank" rel="nofollow"> PMID: 25257292</a></p><p>Mosa et al (2018) Long-term treatment with the ghrelin receptor antagonist [d-Lys3]-GHRP-6 does not improve glucose homeostasis in nonobese diabetic MKR mice. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology <strong>314</strong>(1) R71 <a href="https://pubmed.ncbi.nlm.nih.gov/28903914/" target="_blank" rel="nofollow">PMID: 28903914</a><br></p>
- Sequence:
- H-His-(D)Trp-(D)Lys-Trp-(D)Phe-Lys-NH2
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 5 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble to 0.50 mg/ml in water
- Formula:
- C49H63N13O6
