Exendin-4 (5-39) amide
Product Sizes
Exendin-4 (5-39) amide
£259.00
GH-009
About this Product
- SKU:
- GH-009
- Extra Details:
- Exendin-4 (5-39) is an antagonist of glucagon-like peptide 1 (GLP-1) receptors. GLP-1 is a G protein-coupled receptor (GPCR) that shares sequence identity with other Family B receptors such as those for secretin, glucagon, and vasoactive intestinal peptide. Unlike the full length exendin-4, a GLP-1 agonist, exendin (5-39) antagonizes GLP-1 stimulated insulin release after food intake. Exendin (5-39) also modulates synaptic transmission via glutamate uptake in the dentate gyrus and improves memory impairment in β-amyloid protein-treated rats.
- Molecular Weight:
- 3806.2
- Purity:
- >95% by HPLC
- References:
- <p>Kobayashi et al (2013) Exendin (5-39), an antagonist of GLP-1 receptor, modulates synaptic transmission via glutamate uptake in the dentate gyrus. Brain Res. <strong>1505</strong> 1 https://doi.org/10.1016/j.brainres.2013.01.012.</p><p>Liao et al (2015) In Vitro Metabolic Stability of Exendin-4: Pharmacokinetics and Identification of Cleavage Products. PLoS ONE <strong>10</strong>(2) e0116805.https://doi.org/10.1371/journal.pone.0116805</p>
- Sequence:
- H-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Store desiccated, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Solubility:
- Soluble in dilute acid
- Formula:
- C169H262N44O54S