ERA Alpha17p
Product Sizes
1 mg
£165.00
GE-010-1MG
About this Product
- SKU:
- GE-010
- Additional Names:
- ERA Alpha 295-311|GE-010, GE010, PLMIKRSKKNSLALSLT, ERA Alpha17p, ERA Alpha 295-311 fragment
- Extra Details:
- ERA Alpha17p is a GPER inverse agonist, corresponding to residues 295-311 of the human estrogen receptor A Alpha (ERA Alpha). This 295-311 region is targeted by post-translational modifications and is involved in the recruitment of Ca2+-calmodulin, Hsp70 and the ubiquitin-protein isopeptide ligase E6-associated protein (E6AP), an E3 ligase catalyzing the ubiquitination of ERA Alpha9, as well as associating with ERA Alpha. ERA Alpha17p triggers membrane-initiated pro apoptotic events in both ERA Alpha-positive and -negative breast cancer cell lines with a preference for ERA Alpha-positive cancer cells, and induces a decrease of more than 50% of the size of triple-negative breast tumour xenografts. ERA Alpha17p also exerts GPER mediated anti-hyperalgesic and anti-inflammatory actions in mice.
- Immunogen:
- G protein-coupled estrogen receptors
- Molecular Weight:
- 1899.13
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- Sequence:
- H-Pro-Leu-Met-Ile-Lys-Arg-Ser-Lys-Lys-Asn-Ser-Leu-Ala-Leu-Ser-Leu-Thr-OH
- Shipping Conditions:
- Blue Ice
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
