Spexin
About this Product
- SKU:
- GA-010
- Additional Names:
- Neuropeptide Q, NPQ, Spexin (36 - 49) amidated|Spexin, Neuropeptide Q, NPQ, Spexin-1, Spexin (36 - 49) amidated, 1370290-58-6
- CAS Number:
- 1370290-58-6
- Extra Details:
- Spexin, or neuropeptide Q, is an endogenous galanin receptor 2/3 agonist with EC50 values of 45 and 112 nM respectively, and no significant activity at galanin receptor 1. Spexin is a satiety inducing peptide which inhibits long chain fatty acid uptake by adipocytes and decreases food consumption in diet induced obese mice and rats. Spexin gene expression is markedly down regulated in obese human fat. Spexin also posseses anxiolytic properties.
- Immunogen:
- Galanin receptors
- Molecular Weight:
- 1619.9
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Walewski et al (2014) Spexin is a novel human peptide that reduces adipocyte uptake of long chain fatty acids and causes weight loss in rodents with diet-induced obesity. Obesity<strong> 22</strong>(7) 1643 doi: 10.1002/oby.20725<br></p><p>Kim et al (2014) Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III. Endocrinology <strong>155</strong>(5) 1864 doi: 10.1210/en.2013-2106</p><p>Shuang-Yu et al (2019) Emerging Roles of NPQ/Spexin in Physiology and Pathology. Frontiers in Pharmacology <strong>10</strong> 457 https://www.frontiersin.org/article/10.3389/fphar.2019.00457 </p>
- Sequence:
- Asn-Trp-Thr-Pro-Gln-Ala-Met-Leu-Tyr-Leu-Lys-Gly-Ala-Gln-NH2
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble to 1 mg/ml in water
- Formula:
- C74H114N20O19S
