Fz7-21
About this Product
- SKU:
- FZ-010
- Additional Names:
- FZD7-binding peptide
- CAS Number:
- 2247635-23-8
- Extra Details:
- Fz7-21 is a peptide identified from a phage library that impairs the function of Frizzled 7 (FZD7) in Wnt-β-catenin signalling, binding to the FZD7 extracellular cysteine rich domain (CRD) and altering its conformation and the architecture of its lipid-binding groove. Fz7-21 antagonises Wnt-β-catenin signaling in HEK293 cells stimulated with exogenous WNT3A with an IC50 of 100 nM and also blocks WNT3A-mediated stabilization of β -catenin in mouse L cells. FzD7-21 impairs stem cell function in intestinal organoids.
- Molecular Weight:
- 1796.05
- Purity:
- >95% by hplc
- References:
- Nile et al (2018) A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells. Nat Chem Biol. <strong>14</strong>(6) 582 <a href="https://pubmed.ncbi.nlm.nih.gov/29632413/" target="_blank">PMID: 29632413</a>
- Sequence:
- Ac-Leu-Pro-Ser-Asp-Asp-Leu-Glu-Phe-Trp-Cys-His-Val- Met-Tyr-NH2
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Solubility:
- Soluble in DMSO
- Formula:
- C83H114N18O23S2