WKYMVm
About this Product
- SKU:
- FR-010
- Additional Names:
- Leukocyte chemoattractant peptide|WKYMVm, 187986-17-0, Leukocyte chemoattractant peptide, FR-010
- CAS Number:
- 187986-17-0
- Extra Details:
- WKYMVm is a selective agonist for formyl peptide receptors FPR1, FPR2 (EC50 = 75 pM) and FPR3 (EC50 = 3 nM) when expressed on immune cells. WKYMVm induces Ca2+ mobilization and superoxide production in, and chemotaxic migration of, monocytes and neutrophils. WKYMVm has pleiotropic anti-inflammatory, pro-angiogenic, anti-apoptotic and immunomodulatory effects in various animal models of sepsis, ulcerative colitis, myocardial infarction, ischemic hindlimb and diabetic cutaneous wound healing.
- Immunogen:
- Formyl peptide receptors
- Molecular Weight:
- 856.11
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Christophe et al (2001) The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/Lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2. J.Biol.Chem.<strong> 276</strong> 21585 PMID: 11285256</p><p>Shin (2005) The Synthetic Chemoattractant Peptide WKYMVm Induces Superoxide Production by Human Eosinophils via the Phosphoinositide 3-Kinase-Mediated Activation of ERK1/2. Int Arch Allergy Immunol. <strong>137</strong>(suppl 1) 21 doi: 10.1159/000085428<br></p><p>Kim et al (2019) WKYMVm hexapeptide, a strong formyl peptide receptor 2 agonist, attenuates hyperoxia-induced lung injuries in newborn mice. Sci Rep<strong> 9</strong> 6815 https://doi.org/10.1038/s41598-019-43321-4</p>
- Sequence:
- H-Trp-Lys-Tyr-Met-Val-D-Met-NH2
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble to 2 mg/ml in water
- Formula:
- C41H61N9O7S2
