Hexa-D-arginine
Product Sizes
Hexa-D-arginine
£129.00
FN-010
About this Product
- SKU:
- FN-010
- Additional Names:
- Hexa-d-arginine amide, D6R, Furin Inhibitor II
- CAS Number:
- 673202-67-0
- Extra Details:
- Hexa-D-arginine is an inhibitor of furin, with Ki values of 106 nM, 580 nM and 13.2 μM for furin, PACE4 and PC1 respectively. Pseudomonas aeruginosa exotoxin A (PEA) protein requires furin-mediated cleavage for manifestation of toxicity and hexa-d-arginine effectively blocks PEA-induced cell lysis and is itself noncytotoxic. Administration of hexa-d-arginine to PEA-treated mice significantly improves their survival rate and decreases circulating levels of tumour necrosis factor alpha. Hexa-D-arginine also blocks furin mediated SARS-CoV-2 spike protein cleavage to suppress virus production and cytopathic effects.
- Molecular Weight:
- 954.16
- Purity:
- >95% by hplc
- References:
- <p>Cameron et al (2000) Polyarginines are potent furin inhibitors. J.Biol.Chem. <strong>275</strong> 36741 <a href="https://pubmed.ncbi.nlm.nih.gov/10958789/" target="_blank" rel="nofollow">PMID: 10958789</a></p><p>Sarac et al (2002) The furin inhibitor hexa-D-arginine blocks the activation of Pseudomonas aeruginosa exotoxin A in vivo. Infect Immun.<strong> 70</strong>(12) 7136 <a href="https://pubmed.ncbi.nlm.nih.gov/12438396/" target="_blank" rel="nofollow">PMID: 12438396</a></p><p>Cheng et al (2020) Furin Inhibitors Block SARS-CoV-2 Spike Protein Cleavage to Suppress Virus Production and Cytopathic Effects. Cell Rep. <strong>33</strong>(2) 108254 <a href="https://pubmed.ncbi.nlm.nih.gov/33007239/" target="_blank">PMID: 33007239</a></p><p><a href="https://pubchem.ncbi.nlm.nih.gov/compound/Hexa-D-arginine" target="_blank">PubChem: Hexa-D-arginine</a><br></p>
- Sequence:
- H-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-NH2
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Solubility:
- Soluble to 2 mg/ml in water
- Formula:
- C36H75N25O6