IRL 1620
About this Product
- SKU:
- ER-020
- Additional Names:
- Suc-[Glu9,Ala11,15]-endothelin-1(8-21)
- CAS Number:
- 142569-99-1
- Extra Details:
- IRL 1620 is an N-succinylated endothelin-1 analogue which acts as a highly selective ETB endothelin receptor agonist, with Ki values of 0.016 and 1900 nM at ETB and ETA receptors respectively. IRL 1620 can also discriminate between two subpopulations of ETB receptors, and in vivo IRL 1620 can significantly reduce neurological and motor deficit as well as infarct volume in a pediatric rat model of cerebral ischemia.
- Molecular Weight:
- 1820
- Purity:
- >95% by hplc
- References:
- <p>Takai et al (1992) A potent and specific agonist, Suc-[Glu9,Ala11,15]-endothelin-1(8-21), IRL 1620, for the ETB receptor. Biochem.Biophys.Res.Commun. <strong>184</strong> 953 PMID: 1315540</p><p>Cemazar et al (2005)The endothelin B (ETB) receptor agonist IRL 1620 is highly vasoconstrictive in two syngeneic rat tumour lines: potential for selective tumour blood flow modification. Br J Cancer <strong>93</strong> 98 https://doi.org/10.1038/sj.bjc.6602672</p><p>Cifuentes et al (2018) Neuroprotective Effect of IRL-1620, an Endothelin B Receptor Agonist, on a Pediatric Rat Model of Middle Cerebral Artery. Frontiers in Pediatrics <strong>6 </strong>310 https://www.frontiersin.org/article/10.3389/fped.2018.00310 <br></p>
- Sequence:
- Suc-Asp-Glu-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-OH
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Solubility:
- Soluble to 0.70 mg/ml in water
- Formula:
- C86H117N17O27