BQ 3020
About this Product
- SKU:
- ER-010
- CAS Number:
- 143113-45-5
- Extra Details:
- BQ 3020 is a linear analogue of endothelin-1 (ET-1) which is a highly potent and selective ETB endothelin receptor agonist with Ki values of 0.18 and 970 nM at human ETB and ETA receptors. Intratumour administration of BQ 3020 can attenuate cancer pain by modulating β-endorphin release from squamous cell carcinoma cells in mouse models.
- Molecular Weight:
- 2006.35
- Purity:
- >95% by hplc
- References:
- <p>Ekelund et al (1994) Effects of selective ETB-receptor stimulation on arterial, venous and capillary functions in cat skeletal muscle. Br.J.Pharmacol. <strong>112</strong> 887 <a href="https://pubmed.ncbi.nlm.nih.gov/7921617/" target="_blank" rel="nofollow">PMID: 7921617</a></p><p>Strachan et al (2000) Constriction to ETB receptor agonists, BQ-3020 and sarafotoxin S6c, in human resistance and capacitance vessels in vivo. British J. Clinical Pharmacology <strong>50</strong>: 27<a href="https://pubmed.ncbi.nlm.nih.gov/10886114/" target="_blank" rel="nofollow"> PMID: 10886114</a></p><p>Quang and Schmidt (2010) Peripheral endothelin B receptor agonist-induced antinociception involves endogenous opioids in mice, PAIN <strong>149</strong>(2) 254 <a href="https://pubmed.ncbi.nlm.nih.gov/20206445/" target="_blank" rel="nofollow">PMID: 20206445</a></p>
- Sequence:
- Ac-Leu-Met-Asp-Lys-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-OH
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Solubility:
- Soluble to 0.50 mg/ml in sodium bicarbonate (0.03M)
- Formula:
- C96H140N20O25S