EGFRvIII peptide
Product Sizes
1 mg
£118.00
EP-040-1MG
About this Product
- SKU:
- EP-040
- Additional Names:
- LEEKKGNYV, EGFRvIII peptide, EP-040, EP 040, EP040|PEGFRvIII, Epidermal growth factor receptor variant III peptide
- Extra Details:
- EGFRvIII peptide is a peptide derived from the fusion junction of epidermal growth factor receptor variant III (EGFRvIII), a variant of EGFR with amino acids 6-273 deleted. This spontaneously occurring alteration is found in a high percentage of primary human brain, breast, lung and ovarian tumours making EGFRvIII an ideal target of immunotherapy in EGFRvIII-expressing tumours. EGFRvIII peptide was identified from a number of candidates as the most immunogenic epitope for major histocompatibility complex I (MHC I) binding to induce tumour specific immune responses. In a glioblastoma mouse brain tumour model EGFRvIII peptide co-administered with the toll-like receptor 5 (TLR5) adjuvant Flagellin B induces an increase in CD8+T cells and a decrease in Treg cells, inducing tumour apoptosis, inhibiting tumour growth and increasing survival.
- Immunogen:
- Epitopes,Receptor tyrosine kinases
- Molecular Weight:
- 1078.57
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- Sequence:
- H-Leu-Glu-Glu-Lys-Lys-Gly-Asn-Tyr-Val-OH
- Shipping Conditions:
- Blue Ice
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
