DC432
About this Product
- SKU:
- EI-020
- Additional Names:
- DC432, peptidomimetic, substrate, inhibitor of N-terminal methyltransferase1/2, NTMT1/2, cell permeable, N-terminal methylation, EI-020, EI020, 2388988-70-1
- Extra Details:
- DC432 is a cell permeable analogue of BM30, also available, the first potent peptidomimetic substrate competitive inhibitor of N-terminal methyltransferase1/2 (NTMT1/2), one of a family of enzymes which methylate the A Alpha-N-terminal amines of proteins starting with the canonical X-P-K/R motif. DC432 has been made cell permeable by the addition of five arginine residues to BM30. DC432 decreases the N-terminal methylation level of the regulator of chromosome condensation 1 and SET proteins in HCT116 cells.
- Immunogen:
- Transferases
- Molecular Weight:
- 1313.59
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- Mackie et al (2020) Selective Peptidomimetic Inhibitors of NTMT1/2: Rational Design, Synthesis, Characterization, and Crystallographic Studies. J Med Chem. 63(17) 9512 doi:10.1021/acs.jmedchem.0c00689
- Sequence:
- 4-Hydroxyphenylacetyl-Pro-Lys-Arg-Arg-Arg-Arg-Arg-Arg-NH2
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- We recommend storage desiccated, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in water
- Formula:
- C55H100N28O10
