BM30
About this Product
- SKU:
- EI-010
- Extra Details:
- BM30 is the first potent peptidomimetic inhibitor for N-terminal methyltransferase1/2 (NTMT1/2). BM30 has a half-maximal inhibitory concentration of 0.89 ± 0.10 μM, is a competitive inhibitor to the peptide substrate and is noncompetitive to the cofactor S-adenosylmethionine. BM30 exhibits over 100-fold selectivity for NTMT1/2 among a panel of 41 methyl transferases, showing great potential for high selectivity when targeting the peptide substrate binding site of NTMT1/2. Its cell-permeable analogue DC432 is also available, which can decrease the N-terminal methylation level of the regulator of chromosome condensation 1 and SET proteins in HCT116 cells.
- Molecular Weight:
- 532.64
- Purity:
- >95% by HPLC
- References:
- Mackie et al (2020) Selective Peptidomimetic Inhibitors of NTMT1/2: Rational Design, Synthesis, Characterization, and Crystallographic Studies. J Med Chem. <strong>63</strong>(17) 9512 <a href="https://pubmed.ncbi.nlm.nih.gov/32689795/" target="_blank" rel="nofollow">PMID: 32689795</a>
- Sequence:
- 4-Hydroxyphenylacetyl-Pro-Lys-Arg-NH2
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Store desiccated, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Solubility:
- Soluble in DMSO
- Formula:
- C25H40N8O5