TAT-D1 peptide
Product Sizes
1 mg
£236.00
DA-020-1MG
About this Product
- SKU:
- DA-020
- Additional Names:
- D1 peptide|GRKKRRQRRRPQGSSEDLKKEEAAGIARPL, DA-020, DA020, D1 peptide, TAT-D1 peptide
- Extra Details:
- Tat-D1 peptide is a peptide constructed from amino acids 396-413 of the dopamine D1 receptor C tail - a sequence chosen to include amino acids 404Glu and 405Glu whch were identified to interact with the dopamine D2 receptor - fused at the NH2 terminus to TAT peptide for cell permeability. TAT-D1 peptide blocks the interaction between D1 and D2 receptors, inhibiting D1-D2 heteromer expression and function without affecting other receptor oligomers such as D1-D1 homomers or D2-D5 heteromers. Tat-D1 peptide disruption of the D1-D2 heteromer abolishes its interaction with Gq and attenuates its calcium signalling and functions as a selective antagonist in vitro and in vivo. In animal models, TAT-D1 treatment alleviates behavioural despair symptoms and and exerts antidepressant-like effects in rats, and in addiction models the Tat-D1 peptide reverses SKF83959 induced inhibition of amphetamine sensitization.
- Immunogen:
- Dopamine receptors
- Molecular Weight:
- 3472.97
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- Sequence:
- H-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Gln-Gly-Ser-Ser-Glu-Asp-Leu-Lys-Lys-Glu-Glu-Ala-Ala-Gly-Ile-Ala-Arg-Pro-Leu-OH
- Shipping Conditions:
- Blue Ice
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
