NK20a
Product Sizes
1 mg
£165.00
CY-080-1MG
About this Product
- SKU:
- CY-080
- Additional Names:
- IL-10 inhibitory peptide|NK20a, CY-080, CY080, NMLRNLRNAFSRVKTFFQMK
- Extra Details:
- NK20a is a peptide designed from the structure of the complex of interleukin-10 (IL-10) with IL-10Ra, the ligand binding subunit of the IL-10 receptor. NK20a has excellent specific affinity for IL-10Ra and can function as an IL-10 antagonist. IL-10 is an immune regulatory cytokine with immunosuppressive and anti-inflammatory activity produced by various cells, including T cells, B cells, keratinocytes, mast cells, eosinophils, dendritic cells, monocytes, and macrophages, and it is upregulated in various cancers. In vitro, NK20a exerts anticancer effects on lymphoma B cells and can abolish the suppression effect of IL-10 on macrophages, consistent with the idea that blockade of the IL-10 receptor inhibits cell proliferation and survival. NK20a can also be conjugated with gold nanoparticles to enhance the anticancer efficacy of 5-fluorouracil (5-FU) against the breast cancer cell line BT-474.
- Immunogen:
- Cytokine receptors
- Molecular Weight:
- 2500.33
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- Sequence:
- H-Asn-Met-Leu-Arg-Asn-Leu-Arg-Asn-Ala-Phe-Ser-Arg-Val-Lys-Thr-Phe-Phe-Gln-Met-Lys-OH
- Shipping Conditions:
- Blue Ice
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
