Cibinetide
Product Sizes
1 mg
£165.00
CY-070-1MG
About this Product
- SKU:
- CY-070
- Additional Names:
- ARA 290, Pyroglutamate Helix B Surface Peptide, pHBSP|CY-070, CY070, 1208243-50-8, Cibinetide, ARA 290, Pyroglutamate Helix B Surface Peptide, pHBSP
- CAS Number:
- 1208243-50-8
- Extra Details:
- Cibinetide is a linear nonhematopoietic peptide that mimics the three-dimensional structure of the helix B surface domain of erythropoietin (EPO). Cibinetide binds selectively to the non-hematopoietic EPO receptor (the innate repair receptor, IRR), which is a heterodimer of the EPO receptor and the cytokine family beta common receptor (B BetaCR, CD131). The IRR becomes locally upregulated following tissue injury and its activation initiates a local anti-inflammatory response, inhibition of death signal and anti-apoptosis, preventing overt tissue damage. Cibinetide produces effective and long-term pain relief following peripheral nerve damage, an effect mediated by its anti-inflammatory and immunomodulatory functions, and the IRR is thought to be a point of integration between the immune system and pain signalling via nociception. Cibinetide possesses analgesic and tissue protective effects in many diseases such as diabetes and cancer.
- Immunogen:
- Cytokine receptors
- Molecular Weight:
- 1257.31
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- Sequence:
- Glp-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser-OH (Glp is pyroglutamic acid)
- Shipping Conditions:
- Blue Ice
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
