D1 peptide
Product Sizes
1 mg
£130.00
CY-060-1MG
About this Product
- SKU:
- CY-060
- Additional Names:
- GSETWKTIITKN, D1 peptide, Synthetic IL13RA Alpha2 D1 peptide, IL13RA Alpha2 peptide, CY-060, CY060|IL13RA Alpha2 peptide
- Extra Details:
- D1 is a peptide containing the 81-WKTIITKN-88 conserved sequence from the IL13RA Alpha2 binding site, the full sequence being that which interacts directly with IL-13 in site III. IL13RA Alpha2 is a cancer/testis-like tumour antigen that is overexpressed in various tumours, and in colorectal cancer, IL13RA Alpha2 expression is associated with late stage disease and lower overall survival. D1 blocks IL-13 binding to IL13RA Alpha2 with near complete inhibition at 50ug/ml, and in metastatic colorectal and glioblastoma cancer cells treated with IL-13, D1 peptide inhibits migration, invasion, and proliferation. In vivo, D1 peptide causes a modest increase in survival of mice innoculated with KM12SM colonic cancer cells preincubated with D1, but in contrast, the more stable D1 enantiomer consisting of all D amino acids, D-D1, causes a remarkable increase in survival in animal models, with 40% of mice surviving the experimental endpoint without metastatic lesions in liver. In glioblastoma xenografts, D-D1 peptide administration causes significant growth arrest accompanied by a regression in tumour size. Please contact us for the D-D1 peptide
- Immunogen:
- Cytokine receptors
- Molecular Weight:
- 1376.73
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- Sequence:
- H-Gly-Ser-Glu-Thr-Trp-Lys-Thr-Ile-Ile-Thr-Lys-Asn-OH
- Shipping Conditions:
- Blue Ice
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
