rytvela
About this Product
- SKU:
- CY-030
- Additional Names:
- 101.1|868844-53-5, rytvela, CY030, CY-030, 101.10
- CAS Number:
- 868844-53-5
- Extra Details:
- Rytvela is an all D peptide derived from an extracellular loop region of the interleukin-1 receptor accessory protein (IL-1RAcP), which acts as an allosteric negative modulator of the interleukin-1 receptor (IL-1R). In vitro, rytvela is specific, potent and effective and blocks human thymocyte proliferation with an IC50 of 1 nM, Rytvela does not significantly inhibit NF- K Kappa B, but instead it selectively inhibits the IL-1R downstream stress associated protein kinases/transcription factor c-jun and Rho GTPase/Rho-associated coiled coil containing protein kinase signaling pathways. In vivo rytvela is active in models of hyperthermia and inflammatory bowel disease and topically in contact dermatitis.A scrambled control peptide, rytvela scrambled peptide, is also available.
- Immunogen:
- Cytokine receptors
- Molecular Weight:
- 850.96
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Quiniou et al (2008) Development of a novel noncompetitive antagonist of IL-1 receptor. J Immunol. <strong>180</strong>(10) 6977 <a href="https://pubmed.ncbi.nlm.nih.gov/18453620/" target="_blank" rel="nofollow">PMID: 18453620</a></p><p>Dabouz (2020) An allosteric interleukin-1 receptor modulator mitigates inflammation and photoreceptor toxicity in a model of retinal degeneration. J Neuroinflammation. <strong>17</strong>(1) 359<a href="https://pubmed.ncbi.nlm.nih.gov/33246504/" target="_blank" rel="nofollow"> PMID: 33246504</a></p><p>Takahashi (2021) Direct administration of the non-competitive interleukin-1 receptor antagonist rytvela transiently reduced intrauterine inflammation in an extremely preterm sheep model of chorioamnionitis. PLoS One <strong>16</strong>(9) e0257847 <a href="https://pubmed.ncbi.nlm.nih.gov/34559862/" target="_blank" rel="nofollow">PMID: 34559862</a><br></p>
- Sequence:
- H-(D)Arg-(D)Tyr-(D)Thr-(D)Val-(D)Glu-(D)Leu-(D)Ala-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in water
- Formula:
- C38H62N10O12
